Beyond HIV infection: Neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases.

ABSTRACT: The interactions between chemokine receptors and their ligands may affect susceptibility to infectious diseases as well as their clinical manifestations. These interactions mediate both the traffic of inflammatory cells and virus-associated immune responses. In the context of viral infections, the human C-C chemokine receptor type 5 (CCR5) receives great attention from the scientific community due to its role as an HIV-1 co-receptor. The genetic variant CCR5Δ32 (32 base-pair deletion in CCR5 gene) impairs CCR5 expression on the cell surface and is associated with protection against HIV infection in homozygous individuals. Also, the genetic variant CCR5Δ32 modifies the CCR5-mediated inflammatory responses in various conditions, such as inflammatory and infectious diseases. CCR5 antagonists

SUBMITTER: Ellwanger JH 

PROVIDER: S-EPMC7260533 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature