Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.

ABSTRACT:

Background

Animal models are one of the first steps in translation of basic science findings to clinical practice. For tendon healing research, transgenic mouse models are important to advance therapeutic strategies. However, the small size of the structures complicates surgical approaches, histological assessment, and biomechanical testing. In addition, available models are not standardized and difficult to compare. How surgery itself affects the healing outcome has not been investigated yet. The focus of the study was to develop a procedure that includes a transection and microsurgical reconstruction of the Achilles tendon but, unlike other models, preserves the sciatic nerve. We wanted to examine how distinct parts of the technique influenced healing.

Methods

For this ani

SUBMITTER: Michel PA 

PROVIDER: S-EPMC7260609 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature