Efficacy of Savolitinib vs Sunitinib in Patients With MET-Driven Papillary Renal Cell Carcinoma: The SAVOIR Phase 3 Randomized Clinical Trial.

ABSTRACT:

Importance

Papillary renal cell carcinoma (PRCC) is the most common type of non-clear cell RCC. Because some cases of PRCC are MET-driven, MET inhibition could be a targeted treatment approach. In previous studies, savolitinib (AZD6094, HMPL-504, volitinib), a highly selective MET-tyrosine kinase inhibitor, demonstrated antitumor activity in this patient group.

Objective

To determine whether savolitinib is a better treatment option for this patient population, vs standard of care, sunitinib.

Design, setting, and participants

The SAVOIR phase 3, open-label, randomized clinical trial was a multicenter study carried out in 32 centers in 7 countries between July 2017 and the data cutoff in August 2019. Overall, 360 to 450 patients were to be screened to randomize approxim

SUBMITTER: Choueiri TK 

PROVIDER: S-EPMC7260692 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature