Identification and validation of m⁶A RNA methylation regulators with clinical prognostic value in Papillary thyroid cancer.

ABSTRACT:

Background

Papillary thyroid cancer (PTC) is a type of malignant tumor with excellent prognosis, accounting for more than 80% of thyroid cancer. Recently, numerous studies illustrated the importance of N ⁶-methyladenosine (m⁶A) RNA modification to tumorigenesis, but it has never been reported in PTC.

Methods

We downloaded data from The Cancer Genome Atlas (TCGA) and analyzed RNA expression, single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) of 19 m⁶A RNA methylation regulators in PTC. Then we used nonnegative matrix factorization (NMF) to cluster patients into two m⁶A subtypes and compared them in overall survival (OS) and disease-free survival (DFS). The Weighted correlation network analysis (WGCNA) an

SUBMITTER: Wang X 

PROVIDER: S-EPMC7260751 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature