Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer.

ABSTRACT:

Background

Studies of cancer mutations have typically focused on identifying cancer driving mutations that confer growth advantage to cancer cells. However, cancer genomes accumulate a large number of passenger somatic mutations resulting from various endogenous and exogenous causes, including normal DNA damage and repair processes or cancer-related aberrations of DNA maintenance machinery as well as mutations triggered by carcinogenic exposures. Different mutagenic processes often produce characteristic mutational patterns called mutational signatures. Identifying mutagenic processes underlying mutational signatures shaping a cancer genome is an important step towards understanding tumorigenesis.

Methods

To investigate the genetic aberrations associated with mutational sign

SUBMITTER: Kim YA 

PROVIDER: S-EPMC7260830 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature