Apolipoprotein CIII predicts cardiovascular events in patients with coronary artery disease: a prospective observational study.

ABSTRACT:

Background

Apolipoprotein CIII (apoCIII) is associated with triglyceride-rich lipoprotein metabolism and has emerged as independent marker for risk of cardiovascular disease. The objective was to test whether apoCIII is regulated postprandially and whether apoCIII concentrations in native and chylomicron-free serum predict future cardiovascular events in patients with stable coronary artery disease (CAD).

Methods

ApoCIII concentrations were measured in native and chylomicron-free serum in the fasting state and after a standardized oral fat load test in 195 patients with stable CAD. Clinical follow-up was 48 months. Chylomicron-free serum was prepared by ultracentrifugation (18,000 rpm, 3 h). The log-rank test and Cox regression analyses were used to investigate the associati

SUBMITTER: Katzmann JL 

PROVIDER: S-EPMC7260843 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature