High-yield production of L-serine through a novel identified exporter combined with synthetic pathway in Corynebacterium glutamicum.

ABSTRACT:

Background

L-Serine has wide and increasing applications in industries with fast-growing market demand. Although strategies for achieving and improving L-serine production in Corynebacterium glutamicum (C. glutamicum) have focused on inhibiting its degradation and enhancing its biosynthetic pathway, L-serine yield has remained relatively low. Exporters play an essential role in the fermentative production of amino acids. To achieve higher L-serine yield, L-serine export from the cell should be improved. In C. glutamicum, ThrE, which can export L-threonine and L-serine, is the only identified L-serine exporter so far.

Results

In this study, a novel L-serine exporter NCgl0580 was identified and characterized in C. glutamicum ΔSSAAI (SSAAI), and named as SerE (encoded by serE).

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7260847 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature