Campylobacter jejuni BumSR directs a response to butyrate via sensor phosphatase activity to impact transcription and colonization.

ABSTRACT: Campylobacter jejuni monitors intestinal metabolites produced by the host and microbiota to initiate intestinal colonization of avian and animal hosts for commensalism and infection of humans for diarrheal disease. We previously discovered that C. jejuni has the capacity to spatially discern different intestinal regions by sensing lactate and the short-chain fatty acids acetate and butyrate and then alter transcription of colonization factors appropriately for in vivo growth. In this study, we identified the C. jejuni butyrate-modulated regulon and discovered that the BumSR two-component signal transduction system (TCS) directs a response to butyrate by identifying mutants in a genetic screen defective for butyrate-modulated transcription. The BumSR TCS, which is impor

SUBMITTER: Goodman KN 

PROVIDER: S-EPMC7260946 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature