A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory.

ABSTRACT: The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

SUBMITTER: Zhou M 

PROVIDER: S-EPMC7261007 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature