Comparison of the Elecsys® Anti-SARS-CoV-2 immunoassay with the EDI™ enzyme linked immunosorbent assays for the detection of SARS-CoV-2 antibodies in human plasma.

ABSTRACT:

Background

Here, we report on a head-to-head comparison of the fully-automated Elecsys® Anti-SARS-CoV-2 immunoassay with the EDI^TM enzyme linked immunosorbent assays (ELISA) for the detection of SARS-CoV-2 antibodies in human plasma.

Methods

SARS-CoV-2 antibodies were measured with the Elecsys® assay and the EDI^TM ELISAs (IgM and IgG) in 64 SARS-CoV-2 RT-PCR confirmed COVID-19 patients with serial blood samples (n = 104) collected at different time points from symptom onset. Blood samples from 200 healthy blood donors and 256 intensive care unit (ICU) patients collected before the COVID-19 outbreak were also used.

Results

In COVID-19 patients, the percentage of positive results rose with time from symptom onset, peaking to positivity rates after

SUBMITTER: Egger M 

PROVIDER: S-EPMC7261064 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature