Prefrontal-hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability.

ABSTRACT: Down syndrome (DS) is the most common form of intellectual disability. The cognitive alterations in DS are thought to depend on brain regions critical for learning and memory such as the prefrontal cortex (PFC) and the hippocampus (HPC). Neuroimaging studies suggest that increased brain connectivity correlates with lower intelligence quotients (IQ) in individuals with DS; however, its contribution to cognitive impairment is unresolved. We recorded neural activity in the PFC and HPC of the trisomic Ts65Dn mouse model of DS during quiet wakefulness, natural sleep, and the performance of a memory test. During rest, trisomic mice showed increased theta oscillations and cross-frequency coupling in the PFC and HPC while prefrontal-hippocampal synchronization was strengthened, suggesting hypersyn

SUBMITTER: Alemany-Gonzalez M 

PROVIDER: S-EPMC7261130 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature