New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality.

ABSTRACT:

Objectives

To describe the epidemiology, morbidity, and mortality of new or progressive multiple organ dysfunction syndrome in children with severe sepsis.

Design

Secondary analysis of a prospective, cross-sectional, point prevalence study.

Setting

International, multicenter PICUs.

Patients

Pediatric patients with severe sepsis identified on five separate days over a 1-year period.

Interventions

None.

Measurements and main results

Of 567 patients from 128 PICUs in 26 countries enrolled, 384 (68%) developed multiple organ dysfunction syndrome within 7 days of severe sepsis recognition. Three hundred twenty-seven had multiple organ dysfunction syndrome on the day of sepsis recognition. Ninety-one of these patients developed progressive multiple orga

SUBMITTER: Lin JC 

PROVIDER: S-EPMC7261134 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature