CD4⁺ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection.

ABSTRACT: The underlying mechanisms by which prior immunity to dengue virus (DENV) affords cross-protection against the related flavivirus Zika virus (ZIKV) are poorly understood. Here, we examine the ability of DENV/ZIKV-cross-reactive CD4⁺ T cells to protect against versus exacerbate ZIKV infection by using a histocompatibility leukocyte antigen (HLA)-DRB1^∗0101 transgenic, interferon α/β receptor-deficient mouse model that supports robust DENV and ZIKV replication. By mapping the HLA-DRB1^∗0101-restricted T cell response, we identify DENV/ZIKV-cross-reactive CD4⁺ T cell epitopes that stimulate interferon gamma (IFNγ) and/or tumor necrosis factor (TNF) production. Vaccination of naive HLA-DRB1^∗0101 transgenic mice with these peptides induces a C

SUBMITTER: Wen J 

PROVIDER: S-EPMC7261136 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature