Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.

ABSTRACT: Recent discoveries about functional mechanisms of proteins in the TMEM16 family of phospholipid scramblases have illuminated the dual role of the membrane as both the substrate and a mechanistically responsive environment in the wide range of physiological processes and genetic disorders in which they are implicated. This is highlighted in the review of recent findings from our collaborative investigations of molecular mechanisms of TMEM16 scramblases that emerged from iterative functional, structural, and computational experimentation. In the context of this review, we present new MD simulations and trajectory analyses motivated by the fact that new structural information about the TMEM16 scramblases is emerging from cryo-EM determinations in lipid nanodiscs. Because the functional enviro

SUBMITTER: Khelashvili G 

PROVIDER: S-EPMC7261202 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature