Drug repurposing using computational methods to identify therapeutic options for COVID-19.

ABSTRACT:

Purpose

Recently, the world has been dealing with a new type of coronavirus called COVID-19 that in terms of symptoms is similar to the SARS coronavirus. Unfortunately, researchers could not find a registered therapy to treat the infection related to the virus yet. Regarding the fact that drug repurposing is a good strategy for epidemic viral infection, we applied the drug repurposing strategy using virtual screening to identify therapeutic options for COVID-19. For this purpose, five proteins of COVID-19 (3-chymotrypsin-like protease (3CLpro), Papain-Like protease (PLpro), cleavage site, HR1 and RBD in Spike protein) were selected as target proteins for drug repositioning.

Methods

First, five proteins of COVID-19 were built by homology modeling. Then FDA-approved drugs (247

SUBMITTER: Mahdian S 

PROVIDER: S-EPMC7261216 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature