Radiomic measures from chest high-resolution computed tomography associated with lung function in sarcoidosis.

ABSTRACT:

Introduction

Pulmonary sarcoidosis is a rare heterogeneous lung disease of unknown aetiology, with limited treatment options. Phenotyping relies on clinical testing including visual scoring of chest radiographs. Objective radiomic measures from high-resolution computed tomography (HRCT) may provide additional information to assess disease status. As the first radiomics analysis in sarcoidosis, we investigate the potential of radiomic measures as biomarkers for sarcoidosis, by assessing 1) differences in HRCT between sarcoidosis subjects and healthy controls, 2) associations between radiomic measures and spirometry, and 3) trends between Scadding stages.

Methods

Radiomic features were computed on HRCT in three anatomical planes. Linear regression compared global radiomic feat

SUBMITTER: Ryan SM 

PROVIDER: S-EPMC7261239 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature