Adjusted time-varying population attributable hazard in case-control studies.

ABSTRACT: Population attributable fraction is a widely used measure for quantifying the disease burden associated with a modifiable exposure of interest at the population level. It has been extended to a time-varying measure, population attributable hazard function, to provide additional information on when and how the exposure's impact varies over time. However, like the classic population attributable fraction, the population attributable hazard is generally biased if confounders are present. In this article, we provide a natural definition of adjusted population attributable hazard to take into account the effects of confounders, and its alternative that is identifiable from case-control studies under the rare disease assumption. We propose a novel estimator, which combines the odds ratio estimat

SUBMITTER: Zhao W 

PROVIDER: S-EPMC7261419 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature