Project description:The Covid-19 pandemic is an unprecedented shock that has tested the responsiveness of education systems around the world. The international literature that has studied the Covid-19 pandemic and school performance is still limited. Colombia presents an interesting scenario for the analysis due to the prolonged school closures and long lockdowns it experienced in 2020, and the availability of a rich dataset on the results of a high school exit examination (Saber11) that was administered even during the pandemic. Using this data, we estimate whether the COVID-19 pandemic is associated to lower levels of performance amongst graduating high school students using a school and time fixed effects model, finding a negative relation. Due to the significant reduction in the number of students taking the national standardized high school exit exam in 2020, we use inverse probability weighting (IPW) regressions to control for possible selection bias. The results of these regressions show that the Covid-19 pandemic has a negative and statistically significant relation with the scores obtained by students on the Saber11 exam. These results are relevant because they provide evidence to motivate the design of public policies that mitigate the side effects of the pandemic on educational outcomes.

| S-EPMC10121134 | biostudies-literature

Delayed Colorectal Cancer Care During Coronavirus Disease (COVID-19) Pandemic (DECOR-19)

Project description:To understand and analyse the global impact of COVID-19 on outpatient services, inpatient care, elective surgery, and perioperative colorectal cancer care, a DElayed COloRectal cancer surgery (DECOR-19) survey was conducted in collaboration with numerous international colorectal societies with the objective of obtaining several learning points from the impact of the COVID-19 outbreak on our colorectal cancer patients which will assist us in the ongoing management of our colorectal cancer patients and to provide us safe oncological pathways for future outbreaks.

| 2346925 | ecrin-mdr-crc

The impact of COVID-19 pandemic on colorectal cancer therapy

Project description:Primary outcome(s): The incidence of obstructive colorectal cancer

| 2656898 | ecrin-mdr-crc

Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer

Project description:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread worldwide. Since then, the COVID-19 pandemic has caused a detrimental effect of the national health care system, causing a drastic reduction of the screening programs for colorectal cancer and requiring the redistribution of the hospital resources from elective surgery to the care of patients with SARS-Cov_2 infection requiring admission.

| 2364120 | ecrin-mdr-crc

Managing Colorectal Cancer Prevention Procedure Wait Lists During the COVID-19 Pandemic

Project description:The main objective of this study is to offer and evaluate an interim triage approach for patients waiting for surveillance colonoscopies. This will reduce the waiting period and the psychological stressors for our patients and from a scientific point of view allow us to compare the yield of findings for each approach.

| 2383510 | ecrin-mdr-crc

Modelling, analysis and optimization of socio-economic measures for reducing the negative consequences of the Covid-19 pandemic (in Bulgarian)

Project description: Not available

| S-BSST1076 | biostudies-other

Genome-wide neonatal epigenetic changes associated with maternal exposure to the COVID-19 pandemic

Project description:Background: During gestation, stressors to the fetus, including viral exposure or maternal psychological distress, can fundamentally alter the neonatal epigenome, and may be associated with long-term impaired developmental outcomes. The impact of in utero exposure to the COVID-19 pandemic on the newborn epigenome has yet to be described. Methods: This study aimed to determine whether there are unique epigenetic signatures in newborns who experienced otherwise healthy pregnancies that occurred during the COVID-19 pandemic (Project RESCUE). The pre-pandemic control and pandemic cohorts (Project RESCUE) included in this study are part of a prospective observational and longitudinal cohort study that evaluates the impact of elevated prenatal maternal stress during the COVID-19 pandemic on early childhood neurodevelopment. Using buccal swabs collected at birth, differential DNA methylation analysis was performed using the Infinium MethylationEPIC arrays and linear regression analysis. Pathway analysis and gene ontology enrichment were performed on resultant gene lists. Results: Widespread differential methylation was found between neonates exposed in utero to the pandemic and pre-pandemic neonates. In contrast, there were no apparent epigenetic differences associated with maternal COVID-19 infection during pregnancy. Differential methylation was observed among genomic sites that underpin important neurological pathways that have been previously reported in the literature to be differentially methylated because of prenatal stress, such as NR3C1. Conclusions: The present study reveals that the onset and continuation of the COVID-19 pandemic has fundamentally altered the epigenomes of newborns born during this time, even in otherwise healthy pregnancies, which should be considered in current and future epigenetic studies and may act as a critical biomarker of stress.

2023-11-08 | GSE229463 | GEO

The COVID-19 Pandemic and Clinical Characteristics of Colorectal Cancer: A Multicenter Study

Project description:Primary outcome(s): Clinical characteristics of colorectal cancer Study Design: Observational Study Model : Cohort, Time Perspective : Retrospective, Enrollment : 4000, Biospecimen Retention : Not collect nor Archive

| 26191 | ecrin-mdr-crc

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