Organophosphate flame-retardant metabolite concentrations and pregnancy loss among women conceiving with assisted reproductive technology.

ABSTRACT:

Objective

To evaluate whether urinary concentrations of organophosphate flame retardant (PFR) metabolites are associated with pregnancy loss among women conceiving with assisted reproductive technology (ART).

Design

Prospective preconception cohort of subfertile women.

Setting

Academic hospital fertility center in Boston, Massachusetts.

Patient(s)

A total of 155 women conceiving 179 pregnancies with ART.

Intervention(s)

None. Mean exposure to each of five PFR metabolites was estimated by averaging the specific-gravity adjusted natural log concentrations from two urine samples collected during the ART cycle of conception.

Main outcome measure(s)

Adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for biochemical and total pregnancy loss (

SUBMITTER: Messerlian C 

PROVIDER: S-EPMC7261497 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature