Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients.

ABSTRACT:

Aim

Soluble suppression of tumorigenicity-2 (sST2) is a strong prognostic biomarker in heart failure. The emerging understanding of circadian biology in cardiovascular disease may lead to novel applications in prognosis and diagnosis and may provide insight into mechanistic aspects of the disease-biomarker interaction. So far, it is unknown whether sST2 exhibits a diurnal rhythm. Repeated measurements of sST2 may aid in clinical decision making. The goal of this study was to investigate whether sST2 exhibits diurnal variation in patients with heart failure with reduced ejection fraction (HFrEF) and in control subjects, thereby enhancing its diagnostic and prognostic values.

Methods and results

The study comprised 32 subjects: 16 HFrEF patients and 16 controls. Blood was coll

SUBMITTER: Crnko S 

PROVIDER: S-EPMC7261542 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature