Clinical determinants and prognostic implications of renin and aldosterone in patients with symptomatic heart failure.

ABSTRACT:

Aims

Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis. There are limited data on the associations of renin and aldosterone levels with clinical profiles, treatment response, and study outcomes in patients with HF.

Methods and results

We analysed 2,039 patients with available baseline renin and aldosterone levels in BIOSTAT-CHF (a systems BIOlogy study to Tailored Treatment in Chronic Heart Failure). The primary outcome was the composite of all-cause mortality or HF hospitalization. We also investigated changes in renin and aldosterone levels after administration of mineralocorticoid receptor antagonists (MRAs) in a subset of the EPHESUS trial and in an acute

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC7261568 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature