Determinants of Generic Drug Substitution in the United States.

ABSTRACT:

Background

Some classes of drugs have lower than optimal uptake of generic products. We aimed to understand the determinants of generic drug substitution across classes.

Methods

We conducted a cross-sectional analysis of data from the 2013 MarketScan Commercial Claims and Encounters Database from Truven Health Analytics. We quantified generic substitution rates (GSR) for 26 drug classes, choosing one representative week in November 2013. We used mixed-effects logistic regression to estimate the independent relationship between the determinants of interest and generic substitution for 8 classes with low generic utilization.

Results

The GSRs for most classes exceeded 90%, although some were much lower including thyroid hormones (64%), androgens (74%), estrogens (71%), a

SUBMITTER: Segal JB 

PROVIDER: S-EPMC7261594 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature