Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain.

ABSTRACT:

Background

Maternal obesity prior to or during pregnancy influences fetal growth, predisposing the offspring to increased risk for obesity across the life course. Placental epigenetic mechanisms may underlie these associations. We conducted an epigenome-wide association study to identify placental DNA methylation changes associated with maternal prepregnancy body mass index (BMI) and rate of gestational weight gain at first (GWG1), second (GWG2), and third trimester (GWG3).

Method

Participants of the NICHD Fetal Growth Studies with genome-wide placental DNA methylation (n = 301) and gene expression (n = 75) data were included. Multivariable-adjusted regression models were used to test the associations of 1 kg/m² increase in prepregnancy BMI or 1 kg/week increase i

SUBMITTER: Shrestha D 

PROVIDER: S-EPMC7261634 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature