Gene Expression Profiles in Children With Suspected Sepsis.

ABSTRACT:

Study objective

Sepsis recognition is a clinical challenge in children. We aim to determine whether peripheral blood gene expression profiles are associated with pathogen type and sepsis severity in children with suspected sepsis.

Methods

This was a prospective pilot observational study in a tertiary pediatric emergency department with a convenience sample of children enrolled. Participants were older than 56 days and younger than 18 years, had suspected sepsis, and had not received broad-spectrum antibiotics in the previous 4 hours. Primary outcome was source pathogen, defined as confirmed bacterial source from sterile body fluid or confirmed viral source. Secondary outcome was sepsis severity, defined as maximum therapy required for shock reversal in the first 3 hospital d

SUBMITTER: Balamuth F 

PROVIDER: S-EPMC7261647 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature