MRI and flortaucipir relationships in Alzheimer's phenotypes are heterogeneous.

ABSTRACT:

Objective

To assess the relationships between MRI volumetry and [¹⁸ F]flortaucipir PET of typical and atypical clinical phenotypes of Alzheimer's disease, by genarian (age by decade).

Methods

Five-hundred and sixty-four participants including those with typical (n = 86) or atypical (n = 80) Alzheimer's dementia and normal controls (n = 398) underwent apolipoprotein E genotyping, MRI, flortaucipir, and ¹¹ C-PiB; all 166 Alzheimer's participants were beta-amyloid positive and all controls were beta-amyloid negative. Grey matter volume and flortaucipir standard uptake value ratios were calculated for hippocampus, entorhinal cortex, and neocortex. Ratios of hippocampal-to-neocortical and entorhinal-to-neocortical volume and flortaucipir uptake were also cal

SUBMITTER: Josephs KA 

PROVIDER: S-EPMC7261766 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature