A randomized placebo-controlled PET study of ketamine´s effect on serotonin_1B receptor binding in patients with SSRI-resistant depression.

ABSTRACT: The glutamate N-methyl-D-aspartate receptor antagonist ketamine has a rapid antidepressant effect. Despite large research efforts, ketamine's mechanism of action in major depressive disorder (MDD) has still not been determined. In rodents, the antidepressant properties of ketamine were found to be dependent on both the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and the serotonin (5-HT)_1B receptor. Low 5-HT_1B receptor binding in limbic brain regions is a replicated finding in MDD. In non-human primates, AMPA-dependent increase in 5-HT_1B receptor binding in the ventral striatum (VST) has been demonstrated after ketamine infusion. Thirty selective serotonin reuptake inhibitor-resistant MDD patients were recruited via advertisement and randomiz

SUBMITTER: Tiger M 

PROVIDER: S-EPMC7261801 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature