Circular RNA hsa_circ_0131242 Promotes Triple-Negative Breast Cancer Progression by Sponging hsa-miR-2682.

ABSTRACT:

Objective

CircRNAs are emerging as vital regulators in a variety of cancers. However, the expression pattern and potential mechanism of circRNAs in triple-negative breast cancer remain unclear. In this study, we aim to systematically investigate circRNAs alteration in triple-negative breast cancer tissues.

Methods

Microarray and bioinformatics analyses were used to identify circRNAs expression in cancer tissues. qRT-PCR was conducted to measure the expression of RNAs. Cell Counting Kit-8, wound-healing and transwell assays were conducted to investigate the function of circRNAs. Dual-luciferase reporter assay was performed to validate target binding.

Results

Hsa_circ_0131242 was highly expressed in both cancer tissues and cell lines compared to control. Subsequently, s

SUBMITTER: Li Y 

PROVIDER: S-EPMC7261810 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature