Making "Good" Choices: Social Isolation in Mice Exacerbates the Effects of Chronic Stress on Decision Making.

ABSTRACT: Chronic stress can impact decision-making and lead to a preference for immediate rewards rather than long-term payoffs. Factors that may influence these effects of chronic stress on decision-making are under-explored. Here we used a mouse model to investigate the changes in decision-making caused by the experience of chronic stress and the role of social isolation in exaggerating these changes. To test decision-making, mice were trained to perform a Cost-Benefit Conflict (CBC) task on a T-maze, in which they could choose between a high-reward, high-risk alternative and a low-reward, low-risk alternative. Mice were either housed in groups or alone throughout the experiment. Both groups of mice underwent a seven-day period of repeated immobilization to induce chronic stress. Stress levels we

SUBMITTER: Mudra Rakshasa A 

PROVIDER: S-EPMC7261864 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature