Evaluation of Dosimetry, Quantitative Methods, and Test-Retest Variability of ¹⁸F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain.

ABSTRACT: ¹⁸F-PI-2620 is a next-generation tau PET tracer that has demonstrated ability to image the spatial distribution of suspected tau pathology. The objective of this study was to assess the tracer biodistribution, dosimetry, and quantitative methods of ¹⁸F-PI-2620 in the human brain. Full kinetic modeling to quantify tau load was investigated. Noninvasive kinetic modeling and semiquantitative methods were evaluated against the full tracer kinetics. Finally, the reproducibility of PET measurements from test and retest scans was assessed. Methods: Three healthy controls (HCs) and 4 Alzheimer disease (AD) subjects underwent 2 dynamic PET scans, including arterial sampling. Distribution volume ratio (DVR) was estimated using full tracer kinetics (reversible 2-tissue-co

SUBMITTER: Bullich S 

PROVIDER: S-EPMC7262221 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature