Dataset of quantitative proteomic analysis to understand aging processes in rabbit liver.

ABSTRACT: Here, we present a proteomics dataset of liver proteins to understand aging in rabbits, which complements the publication "Quantitative proteomics to study aging in rabbit liver" [1]. This dataset was generated to understand the molecular basis and metabolic changes of aging processes in liver, which is the main organ involved in metabolism, detoxification, transport, and signaling. Proteins from young, middle, and old age rabbits were extracted and digested. Generated peptides were labeled with light or heavy dimethyl groups at their N-termini, while lysine amines were labeled with TMT10-plex using a cPILOT workflow [2]. Labeled peptides were fractionated by basic pH reverse phase chromatography and analyzed with online reverse phase LC coupled with tandem mass spectrometry (MS/MS and MS<

SUBMITTER: Amin B 

PROVIDER: S-EPMC7262418 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature