Preexisting malignancy abrogates the beneficial effects of CXCR4 blockade during sepsis.

ABSTRACT: Patients with cancer are at an increased risk of developing and dying from sepsis. We previously reported that blockade of the chemokine receptor CXCR4 resulted in decreased CD4⁺ T cell exhaustion and improved survival in a model of polymicrobial sepsis in previously healthy mice. Here, we sought to determine whether CXCR4 blockade could improve mortality and immune dysregulation during sepsis complicated with malignancy. Results in animals inoculated with a lung cancer cell line and subjected to CLP 3 weeks later indicated that CXCR4 was up-regulated on naïve and central memory T cells following sepsis. Of note, and in contrast to results in previously healthy mice, CXCR4 blockade failed to improve survival in cancer septic animals; instead, it actually significantly worsened s

SUBMITTER: Zhang W 

PROVIDER: S-EPMC7262428 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature