NMDARs Translate Sequential Temporal Information into Spatial Maps.

ABSTRACT: Spatial representations of the sensory world are important for brain function. Timing is an essential component of sensory information. Many brain circuits transform the temporal sequence of input activity into spatial maps; however, the mechanisms underlying this transformation are unclear. Different N-methyl-D-aspartate receptor (NMDAR) response magnitudes result in synaptic potentiation or depression. We asked whether NMDAR response magnitude also affects the transformation of temporal information into directional spatial maps. We quantified retinotectal axon branch dynamics in Xenopus optic tectum in response to temporal sequences of visual stimulation. Reducing NMDAR responses by 50% inverts the spatial distribution of branch dynamics along the rostrocaudal axis in response to tempora

SUBMITTER: Hiramoto M 

PROVIDER: S-EPMC7262552 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature