Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC7262567 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
iScience 20200518 6
An ODE model integrating metabolic mechanisms with clinical data reveals an Ohm's law governing lifetime body mass dynamics, where fat and lean tissues are analogous to a parallel nonlinear capacitor and resistor, respectively. The law unexpectedly decouples weight stability (a cell-autonomous property of adipocytes) and weight change (a parabolic trajectory governed by Ohm's law). In middle age, insulin resistance causes fat accumulation to avoid excessive body shrinkage in old age. Moderate mi ...[more]