Reactive oxygen species (ROS) generation as an underlying mechanism of inorganic phosphate (P_i)-induced mineralization of osteogenic cells.

ABSTRACT: Reactive Oxygen Species (ROS) are a natural byproduct of oxygen metabolism. At physiological levels, ROS regulate multiple cellular processes like proliferation, migration, and differentiation. Increased levels of ROS are associated with pathological conditions, such as inflammation and vascular calcification, where they elicit cytotoxic effects. These contrasting outcomes of ROS have also been reported in osteogenic precursor cells. However, the role of ROS in committed osteogenic cells has not been investigated. Cytotoxic and physiologic effects have also been demonstrated for extracellular phosphate (P_i). Specifically, in committed osteogenic cells P_i stimulates their major function (mineralization), however in osteogenic precursors and endothelial cells P_i

SUBMITTER: Khalid S 

PROVIDER: S-EPMC7262875 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature