Chemokine receptor 4 expression is correlated with the occurrence and prognosis of gastric cancer.

ABSTRACT: Gastric cancer (GC) is a common tumor with a low 5-year survival rate. The chemokine receptor 4 (CXCR4) protein contributes to the progression and prognosis of GC, but the relationship between CXCR4 and immune infiltration, somatic copy number alteration (SCNA), tumor purity, tumor mutation burden (TMB), cytolytic activity (CYT), and drug sensitivity in GC is poorly understood. This study aimed to systematically explore the role of CXCR4 in GC. Microarray and RNA-seq data were collected from the Gene Expression Omnibus and The Cancer Genome Atlas. Our analysis shows that CXCR4 is correlated with various types of immune cells. Patients with high CXCR4 expression had a higher fraction of B cells and CD8⁺ T cells, and a lower fraction of CD4⁺ T cells. In addition, high C

SUBMITTER: Li Y 

PROVIDER: S-EPMC7262922 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature