Ontology highlight
ABSTRACT:
SUBMITTER: Katiyar A
PROVIDER: S-EPMC7262932 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Katiyar Arpit A Fujimoto Mitsuaki M Tan Ke K Kurashima Ai A Srivastava Pratibha P Okada Mariko M Takii Ryosuke R Nakai Akira A
FEBS open bio 20200515 6
The mitochondrial unfolded protein response (UPR<sup>mt</sup> ) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cells. However, the detailed mechanisms underlying the UPR<sup>mt</sup> are currently unclear. Here, we show that HSF1 is required for activation of mitochondrial chaperone genes, including HSP60, HSP10, and mtHSP70, in mouse embryonic fibrob ...[more]