Abnormal modulation of amygdala activity in schizophrenia in response to direct- and averted-gaze threat-related facial expressions.

ABSTRACT:

Objective

Reduced amygdala activation in individuals with schizophrenia is thought to contribute to impairments in emotion recognition and social functioning. Recent work, however, suggests that amygdala abnormalities in schizophrenia are more nuanced than generalized hypoactivation and that modulation of amygdala responses across different stimulus types may be more closely related to social functioning than to overall levels of amygdala activation during a task. The authors investigated amygdala modulation during emotion recognition in patients by manipulating the gaze direction of threat-related expressions.

Method

Blood-oxygen-level-dependent functional MRI was used to measure neural activation in 37 healthy volunteers and 35 schizophrenia patients while participants ide

SUBMITTER: Pinkham AE 

PROVIDER: S-EPMC7263022 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature