Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.

ABSTRACT: There are no US Food and Drug Administration-approved therapies for neonatal seizures. Phenobarbital and phenytoin frequently fail to control seizures. There are concerns about the safety of seizure medications in the developing brain. Levetiracetam has proven efficacy and an excellent safety profile in older patients; therefore, there is great interest in its use in neonates. However, randomized studies have not been performed. Our objectives were to study the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment of neonatal seizures. The study was a multicenter, randomized, blinded, controlled, phase IIb trial investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment for neonatal seizures of any cause

SUBMITTER: Sharpe C 

PROVIDER: S-EPMC7263056 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature