Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis.

ABSTRACT: Centromeres pose an evolutionary paradox: strongly conserved in function but rapidly changing in sequence and structure. However, in the absence of damage, centromere locations are usually conserved within a species. We report here that isolates of the pathogenic yeast species Candida parapsilosis show within-species polymorphism for the location of centromeres on two of its eight chromosomes. Its old centromeres have an inverted-repeat (IR) structure, whereas its new centromeres have no obvious structural features but are located within 30 kb of the old site. Centromeres can therefore move naturally from one chromosomal site to another, apparently spontaneously and in the absence of any significant changes in DNA sequence. Our observations are consistent with a model in which all c

SUBMITTER: Ola M 

PROVIDER: S-EPMC7263194 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature