CD38-targeted Immuno-PET of Multiple Myeloma: From Xenograft Models to First-in-Human Imaging.

ABSTRACT: Background Current measurements of multiple myeloma disease burden are suboptimal. Daratumumab is a monoclonal antibody that targets CD38, an antigen expressed on nearly all myeloma cells. Purpose To demonstrate preclinical and first-in-human application of an antibody composed of the native daratumumab labeled with the positron-emitting radionuclide zirconium 89 (⁸⁹Zr) through the chelator deferoxamine (DFO), or ⁸⁹Zr-DFO-daratumumab, for immunologic PET imaging of multiple myeloma. Materials and Methods ⁸⁹Zr-DFO-daratumumab was synthesized by conjugating ⁸⁹Zr to daratumumab with DFO. A murine xenograft model using CD38-positive OPM2 multiple myeloma cells was used to evaluate CD38-specificity of ⁸⁹Zr-DFO-daratumumab. Following success

SUBMITTER: Ulaner GA 

PROVIDER: S-EPMC7263286 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature