Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort.

ABSTRACT: Background Upper extremity MRI and proton MR spectroscopy are increasingly considered to be outcome measures in Duchenne muscular dystrophy (DMD) clinical trials. Purpose To demonstrate the feasibility of acquiring upper extremity MRI and proton (¹H) MR spectroscopy measures of T2 and fat fraction in a large, multicenter cohort (ImagingDMD) of ambulatory and nonambulatory individuals with DMD; compare upper and lower extremity muscles by using MRI and ¹H MR spectroscopy; and correlate upper extremity MRI and ¹H MR spectroscopy measures to function. Materials and Methods In this prospective cross-sectional study, MRI and ¹H MR spectroscopy and functional assessment data were acquired from participants with DMD and unaffected control participants a

SUBMITTER: Forbes SC 

PROVIDER: S-EPMC7263287 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature