Targeting metabolic dependencies in pediatric cancer.

ABSTRACT:

Purpose of review

In an attempt to identify potential new therapeutic targets, efforts to describe the metabolic features unique to cancer cells are increasingly being reported. Although current standard of care regimens for several pediatric malignancies incorporate agents that target tumor metabolism, these drugs have been part of the therapeutic landscape for decades. More recent research has focused on the identification and targeting of new metabolic vulnerabilities in pediatric cancers. The purpose of this review is to describe the most recent translational findings in the metabolic targeting of pediatric malignancies.

Recent findings

Across multiple pediatric cancer types, dependencies on a number of key metabolic pathways have emerged through study of patient tissue

SUBMITTER: Issaq SH 

PROVIDER: S-EPMC7263318 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature