Ovarian Cancer After Prophylactic Salpingectomy in a Patient With Germline BRCA1 Mutation.

ABSTRACT:

Background

Women with germline BRCA1 or BRCA2 mutations have a lifetime risk of ovarian cancer of up to 46%. Opportunistic salpingectomy has been advocated as a risk-reducing strategy owing to increasing recognition of tubal origin, yet evidence of efficacy in this high-risk population is limited.

Case

This is the case of a woman with a BRCA1 mutation who underwent prophylactic mastectomy and bilateral salpingectomy with ovarian retention before the age of 40 years. She did not undergo oophorectomy and subsequently developed stage IV high-grade serous ovarian cancer 4 years after her initial surgery.

Conclusion

More research is needed to determine the role of prophylactic salpingectomy with delayed oophorectomy, optimal timing of completion oophorectomy, and the risks

SUBMITTER: Lugo Santiago N 

PROVIDER: S-EPMC7263355 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature