Identification of Falsified Chloroquine Tablets in Africa at the Time of the COVID-19 Pandemic.

ABSTRACT: Reports that chloroquine and hydroxychloroquine may be effective against COVID-19 have received worldwide attention, increasing the risk of the introduction of falsified versions of these medicines. Five different types of falsified chloroquine tablets were discovered between March 31, 2020 and April 4, 2020, in Cameroon and the Democratic Republic of Congo by locally conducted thin layer chromatographic analysis. Subsequent investigation by liquid chromatography and mass spectrometry in Germany proved the absence of detectable amounts of chloroquine and the presence of undeclared active pharmaceutical ingredients, that is, paracetamol and metronidazole, in four of the samples. The fifth sample contained chloroquine, but only 22% of the declared amount. Such products represent a serious ri

SUBMITTER: Gnegel G 

PROVIDER: S-EPMC7263564 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature