Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks.

ABSTRACT: Forces generated by the actomyosin cytoskeleton are key contributors to many morphogenetic processes. The actomyosin cytoskeleton organises in different types of networks depending on intracellular signals and on cell-cell and cell-extracellular matrix (ECM) interactions. However, actomyosin networks are not static and transitions between them have been proposed to drive morphogenesis. Still, little is known about the mechanisms that regulate the dynamics of actomyosin networks during morphogenesis. This work uses the Drosophila follicular epithelium, real-time imaging, laser ablation and quantitative analysis to study the role of integrins on the regulation of basal actomyosin networks organisation and dynamics and the potential contribution of this role to cell shape. We find that elimin

SUBMITTER: Santa-Cruz Mateos C 

PROVIDER: S-EPMC7263567 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature