Plasma glucocorticogenic activity, race/ethnicity and alcohol intake among San Francisco Bay Area women.

ABSTRACT: Racial and ethnic minorities are at higher risk for a variety of diseases. While sociodemographic and lifestyle factors contribute to racial/ethnic health disparities, the biological processes underlying these associations remain poorly understood. Stress and its biological consequences through the glucocorticoid receptor (GR) have been hypothesized to mediate adverse disease outcomes. In fasting morning samples of 503 control women from the San Francisco Bay Area Breast Cancer Study, we used a sensitive Chemical-Activated LUciferase gene eXpression (CALUX) assay to examine the association of sociodemographic and lifestyle factors with plasma glucocorticogenic (G) activity in three racial/ethnic groups. The G activity is a sensitive measure that reflects biological activity of total plasma

SUBMITTER: Tachachartvanich P 

PROVIDER: S-EPMC7263601 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature