Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development.

ABSTRACT: Schistosomes are parasitic blood flukes that survive for many years within the mammalian host vasculature. How the parasites establish a chronic infection in the hostile bloodstream environment, whilst evading the host immune response is poorly understood. The parasite develops morphologically and grows as it migrates to its preferred vascular niche, avoiding or repairing damage from the host immune system. In this study, we investigated temporal changes in gene expression during the intra-mammalian development of Schistosoma mansoni. RNA-seq data were analysed from parasites developing in the lung through to egg-laying mature adult worms, providing a comprehensive picture of in vivo intra-mammalian development. Remarkably, genes involved in signalling pathways, developmental control, and

SUBMITTER: Wangwiwatsin A 

PROVIDER: S-EPMC7263636 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature