Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.

ABSTRACT: Sex differences in the incidence and progression of many liver diseases, including liver fibrosis and hepatocellular carcinoma, are associated with sex-biased hepatic expression of hundreds of genes. This sexual dimorphism is largely determined by the sex-specific pattern of pituitary growth hormone secretion, which controls a transcriptional regulatory network operative in the context of sex-biased and growth hormone-regulated chromatin states. Histone H3K27-trimethylation yields a major sex-biased repressive chromatin mark deposited at many strongly female-biased genes in male mouse liver, but not at male-biased genes in female liver, and is catalyzed by polycomb repressive complex-2 through its homologous catalytic subunits, Ezh1 and Ezh2. Here, we used Ezh1-knockout mice with a hepatoc

SUBMITTER: Lau-Corona D 

PROVIDER: S-EPMC7263639 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature