Divergence of Peroxisome Membrane Gene Sequence and Expression Between Yeast Species.

ABSTRACT: Large population-genomic sequencing studies can enable highly-powered analyses of sequence signatures of natural selection. Genome repositories now available for Saccharomyces yeast make it a premier model for studies of the molecular mechanisms of adaptation. We mined the genomes of hundreds of isolates of the sister species S. cerevisiae and S. paradoxus to identify sequence hallmarks of adaptive divergence between the two. From the top hits we focused on a set of genes encoding membrane proteins of the peroxisome, an organelle devoted to lipid breakdown and other specialized metabolic pathways. In-depth population- and comparative-genomic sequence analyses of these genes revealed striking divergence between S. cerevisiae and S. paradoxus And from trans

SUBMITTER: Dubin CA 

PROVIDER: S-EPMC7263690 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature