Blood pressure, heart rate, and mortality in chronic obstructive pulmonary disease: the SUMMIT trial.

ABSTRACT:

Aims

To characterize the relationship between blood pressure (BP) or heart rate and mortality and morbidity in chronic obstructive pulmonary disease (COPD).

Methods and results

We performed post hoc analysis of baseline BP or heart rate and all-cause mortality and cardiovascular events in the SUMMIT trial. SUMMIT was a randomized double-blind outcome trial of 16 485 participants (65 ± 8 years, 75% male, and 47% active smokers) enrolled at 1368 sites in 43 countries. Participants with moderate COPD with or at risk for cardiovascular disease (CVD) were randomized to placebo, long-acting beta agonist, inhaled corticosteroid, or their combination. All-cause mortality increased in relation to high systolic [≥140 mmHg; hazard ratio (HR) 1.27, 95% confidence interval (CI) 1.12-1.45

SUBMITTER: Byrd JB 

PROVIDER: S-EPMC7263699 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature